NFATc1 autoregulation: a crucial step for cell-fate determination
Trends in Immunology, ISSN: 1471-4906, Vol: 27, Issue: 10, Page: 461-469
2006
- 62Citations
- 45Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations62
- Citation Indexes62
- 62
- CrossRef57
- Captures45
- Readers45
- 45
Review Description
Nuclear factor of activated T cell c (NFATc) transcription factors appeared in evolution with the emergence of lymphocytes in jawed fish. They have decisive roles in the development of the immune system and adaptive immune responses. Following immunoreceptor stimulation, NFAT factors control the expression of a large set of genes and thereby the fate of peripheral lymphocytes. NFATc1 and NFATc2 are the most prominent NFAT factors in peripheral T cells; they overlap in their function but differ remarkably in the mode of expression. NFATc2 is constitutively synthesized in T cells, whereas the expression of NFATc1/αA, the most prominent of six NFATc1 isoforms in peripheral T cells, is strongly induced following T-cell receptor and co-receptor stimulation and maintained by positive autoregulation. Findings concerning NFATc1 autoregulation in peripheral T lymphocytes and other cells suggest that positive autoregulation of NFATc1 is a crucial step in cell-fate determination.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1471490606002432; http://dx.doi.org/10.1016/j.it.2006.08.005; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748454137&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/16931157; https://linkinghub.elsevier.com/retrieve/pii/S1471490606002432; https://dx.doi.org/10.1016/j.it.2006.08.005
Elsevier BV
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