Enhancer–promoter communication and transcriptional regulation of Igh
Trends in Immunology, ISSN: 1471-4906, Vol: 32, Issue: 11, Page: 532-539
2011
- 48Citations
- 94Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations48
- Citation Indexes48
- 48
- CrossRef45
- Captures94
- Readers94
- 94
Review Description
Transcriptional regulation of eukaryotic protein-coding genes requires the participation of site-specific transcription factors that bind distal regulatory elements, as well as factors that, together with RNA polymerase II, form the basal transcription machinery at the core promoter. Gene regulation requires proper communication between promoters and enhancers, often over great distances. Therefore, it is important to understand the potentially inter-related transcription factor interactions at both of these elements. How this is achieved on tissue-specific genes, such as the immunoglobulin heavy chain (IgH) in B cells remains unclear. Here, we review known interactions at the Igh variable region (V H ) promoters and present our perspective on promoter–enhancer interactions that are likely important for Ig gene regulation in B cells.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1471490611001189; http://dx.doi.org/10.1016/j.it.2011.06.012; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=82455164195&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21855411; https://linkinghub.elsevier.com/retrieve/pii/S1471490611001189; http://www.cell.com/trends/immunology/abstract/S1471-4906(11)00118-9?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471490611001189%3Fshowall%3Dtrue
Elsevier BV
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