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NLRC5: back to innate immunity

Trends in Immunology, ISSN: 1471-4906, Vol: 45, Issue: 8, Page: 571-573
2024
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Article Description

NLRC5 is a transcriptional regulator of genes governing T cell responses. Most characterized NLRs are instead innate immune sensors forming complexes leading to pyroptosis. Raising exciting questions, Sundaram and colleagues now demonstrate that NLRC5 forms large complexes and causes PANoptosis (immunogenic cell death), in response to heme in inflammatory contexts.

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