Metabolically-Healthy Obesity and Coronary Artery Calcification
Journal of the American College of Cardiology, ISSN: 0735-1097, Vol: 63, Issue: 24, Page: 2679-2686
2014
- 213Citations
- 128Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations213
- Citation Indexes212
- 212
- CrossRef208
- Policy Citations1
- Policy Citation1
- Captures128
- Readers128
- 126
- Mentions1
- Blog Mentions1
- Blog1
Article Description
The purpose of this study was to compare the coronary artery calcium (CAC) scores of metabolically-healthy obese (MHO) and metabolically healthy normal-weight individuals in a large sample of apparently healthy men and women. The risk of cardiovascular disease among obese individuals without obesity-related metabolic abnormalities, referred to as MHO, is controversial. We conducted a cross-sectional study of 14,828 metabolically-healthy adults with no known cardiovascular disease who underwent a health checkup examination that included estimation of CAC scores by cardiac tomography. Being metabolically healthy was defined as not having any metabolic syndrome component and having a homeostasis model assessment of insulin resistance <2.5. MHO individuals had a higher prevalence of coronary calcification than normal weight subjects. In multivariable-adjusted models, the CAC score ratio comparing MHO with normal-weight participants was 2.26 (95% confidence interval: 1.48 to 3.43). In mediation analyses, further adjustment for metabolic risk factors markedly attenuated this association, which was no longer statistically significant (CAC score ratio 1.24; 95% confidence interval: 0.79 to 1.96). These associations did not differ by clinically-relevant subgroups. MHO participants had a higher prevalence of subclinical coronary atherosclerosis than metabolically-healthy normal-weight participants, which supports the idea that MHO is not a harmless condition. This association, however, was mediated by metabolic risk factors at levels below those considered abnormal, which suggests that the label of metabolically healthy for obese subjects may be an artifact of the cutoff levels used in the definition of metabolic health.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0735109714020518; http://dx.doi.org/10.1016/j.jacc.2014.03.042; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902597909&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24794119; https://linkinghub.elsevier.com/retrieve/pii/S0735109714020518; https://dx.doi.org/10.1016/j.jacc.2014.03.042; http://linkinghub.elsevier.com/retrieve/pii/S0735109714020518
Elsevier BV
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