IQGAP1 is a phosphoinositide effector and kinase scaffold
Advances in Biological Regulation, ISSN: 2212-4926, Vol: 60, Page: 29-35
2016
- 75Citations
- 37Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations75
- Citation Indexes75
- 40
- CrossRef33
- Captures37
- Readers37
- 37
Review Description
Phosphatidylinositol 4,5-bisphosphate (PI4,5P 2 ) is a lipid messenger that regulates a wide variety of cellular functions. The majority of cellular PI4,5P 2 is generated by isoforms of the type I phosphatidylinositol phosphate kinases (PIPKI) that are generated from three genes, and each PIPKI isoform has a unique distribution and function in cells. It has been shown that the signaling specificity of PI4,5P 2 can be determined by a physical association of PIPKs with PI4,5P 2 effectors. IQGAP1 is newly identified as an interactor of multiple isoforms of PIPKs. Considering the versatile roles of IQGAP1 in cellular signaling pathways, IQGAP1 may confer isoform-specific roles of PIPKs in distinct cellular locations. In this mini review, the emerging roles of PIPKs that are regulated by an association with IQGAP1 will be summarized. Focuses will be on cell migration, vesicle trafficking, cell signaling, and nuclear events.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2212492615300270; http://dx.doi.org/10.1016/j.jbior.2015.10.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84958770028&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/26554303; https://linkinghub.elsevier.com/retrieve/pii/S2212492615300270
Elsevier BV
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