Multistage pH-responsive mesoporous silica nanohybrids with charge reversal and intracellular release for efficient anticancer drug delivery
Journal of Colloid and Interface Science, ISSN: 0021-9797, Vol: 555, Page: 82-93
2019
- 41Citations
- 38Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations41
- Citation Indexes41
- 41
- CrossRef39
- Captures38
- Readers38
- 38
Article Description
This study introduced multistage pH-responsive nanohybrids (MSN-hyd-MOP) based on mesoporous silica nanoparticles (MSNs) modified with polymers with charge-reversal property via an acid-labile hydrazone linker, which were applied as a drug delivery system loaded anticancer drugs. In this study, MSN-hyd-MOP nanohybrids were completely investigated for their synthesis, pH response, drug release behavior, cytotoxicity capability and endocytic behavior. Responding to the acidic extracellular microenvironment of solid tumor (pH 6.5), MSN-hyd-MOP nanohybrids exhibited surface charge-reversal characteristic from negative (−10.2 mV, pH 7.4) to positive (16.6 mV, pH 6.5). The model drug doxorubicin (Dox) was efficiently loaded within the channels of MSN-hyd-MOP (encapsulation efficiency about 87%). The increased acidity in endo-/lysosome promote Dox-loaded MSN-hyd-MOP (MSN-hyd-MOP@Dox) release Dox quickly. In vitro study revealed the drug delivery system had good biocompatibility and could deliver the payload to tumor cells. Overall, the described nanohybrids can be used as a potential anticancer drug delivery system.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021979719308410; http://dx.doi.org/10.1016/j.jcis.2019.07.061; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85069897059&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/31377647; https://linkinghub.elsevier.com/retrieve/pii/S0021979719308410; https://dx.doi.org/10.1016/j.jcis.2019.07.061
Elsevier BV
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