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Necroptosis Is an Important Severity Determinant and Potential Therapeutic Target in Experimental Severe Pancreatitis

Cellular and Molecular Gastroenterology and Hepatology, ISSN: 2352-345X, Vol: 2, Issue: 4, Page: 519-535
2016
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Article Description

Severe acute pancreatitis is characterized by acinar cell death and inflammation. Necroptosis is an aggressive and proinflammatory mode of cell death that can be prevented by necrostatin-1 administration or receptor-interacting protein kinase (RIP3) deletion.

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