Development of a thermostable oxytocin microneedle patch
Journal of Controlled Release, ISSN: 0168-3659, Vol: 337, Page: 81-89
2021
- 11Citations
- 38Captures
- 1Mentions
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef2
- Captures38
- Readers38
- 38
- Mentions1
- News Mentions1
- News1
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Development of a thermostable oxytocin microneedle patch
Oxytocin is a nonapeptide hormone used in labor to initiate uterine contractions and to prevent and treat postpartum hemorrhage. Oxytocin is currently administered by injection and requires refrigerated
Article Description
Oxytocin is a nonapeptide hormone used in labor to initiate uterine contractions and to prevent and treat postpartum hemorrhage. Oxytocin is currently administered by injection and requires refrigerated transport and storage, which limits access, especially during home birth in developing countries. Here, we propose a thermostable, simple-to-administer microneedle (MN) patch for rapid delivery of oxytocin suitable for use by healthcare workers with limited training, like traditional birth attendants. Oxytocin (10 IU, 16.8 μg) coated onto stainless steel MN arrays was released into skin within 1–5 min after manual insertion. Among tested excipients, polyacrylic acid was best at stabilizing oxytocin stored at 75% relative humidity, with no significant loss for up to 2 months at 40 °C. Under desiccated conditions, MNs coated with formulations containing trehalose in a mixture of citrate buffer and ethanol retained 75% oxytocin potency at 40 °C for 12 months; the commercial oxytocin product Pitocin® was reduced to 35% potency under these conditions. These findings support development of MN patches for oxytocin administration with improved ease of use, extended thermostability and simplified logistics to enable greater access to this life-saving medicine.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0168365921003540; http://dx.doi.org/10.1016/j.jconrel.2021.07.011; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85110500173&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34265331; https://linkinghub.elsevier.com/retrieve/pii/S0168365921003540; https://dx.doi.org/10.1016/j.jconrel.2021.07.011
Elsevier BV
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