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Immunohistochemical Characterization of Peroxisome Proliferator-Activated Receptors in Canine Normal Testis and Testicular Tumours

Journal of Comparative Pathology, ISSN: 0021-9975, Vol: 149, Issue: 1, Page: 10-18
2013
  • 5
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  • 0
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  • 30
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  • 2
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Top Endocrine Publications of 2013: Canine and Feline Reproductive Endocrinology

In my tenth compilation of the canine and feline endocrine publications, I?m moving on to endocrine disorders of the canine and feline gonads and mammary gland.?Listed below are 20 papers published in 2013 that deal with a variety of topics of importance for reproductive endocrinology in dogs and cats. Of all of these publications, one of the most common and clinically useful topics involves the u

Article Description

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Recent studies have demonstrated that PPARs regulate lipid metabolism and are expressed in various cancers. The aim of the present study was to investigate the expression of PPAR-α, -β and -γ in normal canine testicular tissue and canine testicular tumours (CTTs). Expression of PPAR-α, -β and -γ was greater ( P <0.05) than in normal testicular tissue. PPARs were therefore induced in CTTs and they may play a role in the biology of these tumours.

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