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Serotonin and ionizing radiation synergistically affect proliferation and adhesion molecule expression of malignant melanoma cells

Journal of Dermatological Science, ISSN: 0923-1811, Vol: 68, Issue: 2, Page: 89-98
2012
  • 12
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  • 17
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Article Description

Mast cells are key effectors of the immune system and are involved in a variety of physiological and pathophysiological processes. Dermal mast cells have been demonstrated to degranulate as a consequence of ionizing radiation exposure. Mast cells accumulate at the periphery of skin tumours including malignant melanoma. Melanoma cells thus represent a potential target for the action of mediators released from irradiated mast cells.

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