Risk factors for sepsis and effects of pretreatment with systemic steroid therapy for underlying condition in SJS/TEN patients: Results of a nationwide cross-sectional survey in 489 Japanese patients
Journal of Dermatological Science, ISSN: 0923-1811, Vol: 107, Issue: 2, Page: 75-81
2022
- 8Citations
- 13Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes7
- Policy Citations1
- Policy Citation1
- Captures13
- Readers13
- 13
Article Description
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening severe cutaneous adverse reactions (SCARs). Sepsis has been shown to be the main cause of death in SJS/TEN. The European SCAR study reported that 14.8 % of SJS/TEN patients were receiving systemic steroid therapy for their underlying condition prior to onset. However, it remained unclear whether this factor affected the mortality rate. This study was performed to identify risk factors for sepsis in SJS/TEN patients. In addition, we compared patients who had and had not received systemic steroid therapy for their underlying condition. A primary survey regarding the numbers of SJS/TEN patients between 2016 and 2018 was sent to 1205 institutions in Japan. A secondary survey seeking more detailed information was sent to institutions reporting SJS/TEN patients. We analyzed 315 SJS patients and 174 TEN patients using a logistic regression model, Wilcoxon’s rank-sum test, χ 2 test, and Fisher’s exact test. Significant risk factors for sepsis included TEN, diabetes, and intensive care unit (ICU) admission. The mortality rate was significantly higher among patients with sepsis. Patients who had received systemic steroid therapy had a lower incidence of fever, and showed a higher mortality rate. Based on a nationwide epidemiological survey of SJS/TEN in Japan, we identified risk factors for sepsis and found that patients who had received steroid therapy for their underlying condition had a lower incidence of fever and a higher mortality rate.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0923181122001669; http://dx.doi.org/10.1016/j.jdermsci.2022.07.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85134802853&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35882616; https://linkinghub.elsevier.com/retrieve/pii/S0923181122001669; https://dx.doi.org/10.1016/j.jdermsci.2022.07.004
Elsevier BV
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