Antidiabetic effect of Cordia morelosana , chemical and pharmacological studies
Journal of Ethnopharmacology, ISSN: 0378-8741, Vol: 251, Page: 112543
2020
- 13Citations
- 60Captures
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Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef6
- Captures60
- Readers60
- 60
Article Description
Standley (Boraginaceae) is commonly used in folk medicine for the treatment of diarrhoea, kidney inflammation, diabetes, lung pain, bronchitis, asthma, hoarseness, cough and fever. Current work was conducted to develop a bio-guided isolation of antidiabetic compounds from ethanolic extract of Cordia morelosana (EE Cm ). The phytochemical bio-guided study was conducted by successive chromatographic techniques, and isolated compounds were characterized by 1D and 2D-NMR experiments. The in vivo antihyperglycemic and antidiabetic activities of EE Cm (100 mg/kg), and methyl rosmarinate ( MR, 50 mg/kg) were determined on normoglycemic and diabetic murine models. Additionally, the in vitro activity was conducted to determine α-glucosidase inhibitory effect, and PPARs, GLUT4 and FATP expression on 3T3-L1 cells by RT-PCR. Acute and sub-chronic toxicological studies for EE Cm were conducted on rats, following the OECD guidelines (No. 420 and 407). EE Cm promotes significant α-glucosidase inhibition (55.6%) at 1 mg/kg respect to the control. Also, EE Cm (100 mg/kg) showed significant antihyperglycemic effect on oral glucose tolerance test (OGTT), and in non-insulin dependent type 2 diabetes (NIDD) model, had antidiabetic activity (p < 0.001) compared to controls. The bio-guided isolation allowed to obtain four known compounds described as rosmarinic acid ( RA ), methyl rosmarinate ( MR ), nicotiflorine and 1- O -methyl-scyllo-inositol. On the other hand, MR showed significant antidiabetic and anthiyperglycemic activities (p < 0.05), and overexpression of PPARγ, PPARα, GLUT-4 and FATP than control. Docking studies were conducted with PPARγ and PPARα, showing interesting binding mode profile on those targets. Finally, EE Cm displayed a LD 50 > 2000 mg/kg and sub-chronic toxicological study reveals no toxic signs in animals tested compared to control. EE Cm showed significant antihyperglycemic and antidiabetic actions being RA and MR the main antidiabetic metabolites.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0378874119339509; http://dx.doi.org/10.1016/j.jep.2020.112543; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85077980547&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/31917279; https://linkinghub.elsevier.com/retrieve/pii/S0378874119339509; https://dx.doi.org/10.1016/j.jep.2020.112543
Elsevier BV
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