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The Interleukin-1 receptor antagonist is a direct target gene of PPARα in liver

Journal of Hepatology, ISSN: 0168-8278, Vol: 46, Issue: 5, Page: 869-877
2007
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Article Description

The Peroxisome Proliferator-Activated Receptor (PPAR) α belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARα also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes. The objective of this study was to further characterize the role of PPARα in inflammatory gene regulation in liver.

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