Copper(II) thiosemicarbazonate molecular modifications modulate apoptotic and oxidative effects on U937 cell line
Journal of Inorganic Biochemistry, ISSN: 0162-0134, Vol: 116, Page: 195-203
2012
- 22Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef11
- Captures24
- Readers24
- 24
Article Description
To improve the solubility in aqueous media of bis(citronellalthiosemicarbazonato)copper(II) [Cu(S-tcitr) 2 ], a compound that is effective in inhibiting cell growth of U937 cell line, the ligand was modified adding an ethylmorpholine group. [Cu(S-tcitr) 2 ] and [Cu(Etmorph-S-tcitr) 2 ] cytotoxic effects are compared using as a model U937 cells. [Cu(Etmorph-S-tcitr) 2 ] results more effective in cell growth inhibition (IC 50: 2.3 vs 14.8 μM). Apoptosis in [Cu(Etmorph-S-tcitr) 2 ] treated cells was apparent after 8 h, with increased caspase activities, and these effects were not observed for [Cu(S-tcitr) 2 ]. During the exposure to [Cu(Etmorph-S-tcitr) 2 ], ROS (reactive oxygen species) and TBARS (Thiobarbituric acid reactive substances) significantly increased, coupled with reduced glutathione (GSH) levels and significant activation of superoxide dismutase (SOD). These intracellular scavengers seem to limit the early ROS and TBARS increases in U937 cells exposed to [Cu(S-tcitr) 2 ]. Both complexes interacted in vitro with naked DNA: UV–visible and CD titration reveal that they can induce DNA structure modifications in a distinct way. Furthermore, the complexes induced DNA damage on U937 cells at concentrations higher than IC 50. The mechanisms of action and the effects of these two complexes are remarkably different even though they have the same coordination geometry around copper(II) and differ only for the presence of the ethylmorpholine group.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0162013412002231; http://dx.doi.org/10.1016/j.jinorgbio.2012.07.006; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84867191070&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/23063788; https://linkinghub.elsevier.com/retrieve/pii/S0162013412002231; https://dx.doi.org/10.1016/j.jinorgbio.2012.07.006
Elsevier BV
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