Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain
Journal of Neuroimmunology, ISSN: 0165-5728, Vol: 146, Issue: 1, Page: 39-45
2004
- 42Citations
- 36Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef33
- Captures36
- Readers36
- 36
Article Description
Here we report a comparative analysis of interleukin-16 (IL-16) expression by microglial cells of the normal rat brain in trimethyltin (TMT) neurotoxicity, experimental autoimmune uveitis (EAU), encephalomyelitis (EAE), and viral infection (Borna disease, Borna disease virus) by immunohistochemistry. Striking differences were observed. In contrast to the human brain, IL-16 was not expressed constitutively in the rat brain. Remote activation of microglial cells of the optic tract in EAU did not result into IL-16 expression. TMT intoxication induced expression in microglial cells of the hippocampus. In EAE and BDV, massive IL-16 + microglial cells could be seen. Thus, IL-16 is a descriptor of microglial cell activation that discriminates between different disease models, and might be a valuable marker for the detection of microglia activation in human and rat central nervous system (CNS) diseases.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0165572803003941; http://dx.doi.org/10.1016/j.jneuroim.2003.09.017; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0347362897&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/14698845; https://linkinghub.elsevier.com/retrieve/pii/S0165572803003941; https://dx.doi.org/10.1016/j.jneuroim.2003.09.017
Elsevier BV
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