Co-regulated decrease of Neurokinin-1 receptor and Hemokinin-1 gene expression in monocytes and macrophages after activation with pro-inflammatory cytokines
Journal of Neuroimmunology, ISSN: 0165-5728, Vol: 187, Issue: 1, Page: 83-93
2007
- 22Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations22
- Citation Indexes22
- 22
- CrossRef21
- Captures7
- Readers7
Article Description
Hemokinin-1 (HK-1), a potent ligand for the Neurokinin-1 receptor (NK-1) is thought to play a role in the immune system. To investigate the regulation of this receptor–ligand pair, we examined the effects of pro-inflammatory cytokines on their expression in the monocyte/macrophage cell lines Wehi-3 and RAW264.7. We demonstrate co-expression of NK-1 and HK-1 mRNA in both lines, as well as functional NK-1 receptor protein in Wehi-3 cells. Stimulation with IFN-γ, IL-1β and TNF-α markedly decreased NK-1 and HK-1 mRNA as well as NK-1 receptor protein, which coincided with monocytic differentiation. A co-regulated decrease could also be observed in differentiating primary bone marrow macrophages, suggesting that this receptor–ligand pair may be controlled by cytokine networks and may serve a developmental role in the immune system.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0165572807001336; http://dx.doi.org/10.1016/j.jneuroim.2007.04.019; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34347328267&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/17537522; https://linkinghub.elsevier.com/retrieve/pii/S0165572807001336; https://dx.doi.org/10.1016/j.jneuroim.2007.04.019
Elsevier BV
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