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The role of CSF biomarkers in the diagnostic work-up of mixed vascular-degenerative dementia

Journal of the Neurological Sciences, ISSN: 0022-510X, Vol: 322, Issue: 1, Page: 197-199
2012
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Article Description

Low average specificity levels of 48% for clinical diagnosis of possible Alzheimer's disease (AD) reflect the overlap of clinical profiles between AD and non-AD dementias. Should diagnostic errors occur, they most likely involve one of the other primary dementias, mixed pathologies that include a vascular component, or uncertainties that are associated with early diagnosis. Vascular dementia (VaD) is overdiagnosed when a routine brain MRI or CT scan is used in the context of standard clinical diagnostic criteria, meanwhile denying significant neurodegenerative co-pathology.

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