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D-dimer level and outcome of minor ischemic stroke with large vessel occlusion

Journal of the Neurological Sciences, ISSN: 0022-510X, Vol: 413, Page: 116814
2020
  • 21
    Citations
  • 0
    Usage
  • 27
    Captures
  • 0
    Mentions
  • 34
    Social Media
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Metrics Details

  • Citations
    21
  • Captures
    27
  • Social Media
    34
    • Shares, Likes & Comments
      34
      • Facebook
        34

Article Description

To determine the predictors of unfavorable outcomes in acute minor ischemic stroke patients with large vessel occlusion. The derivation cohort included ischemic stroke patients admitted to a comprehensive stroke center within 7 days after onset with large vessel occlusion and an initial National Institutes of Health Stroke Scale score of 5 or less. An unfavorable outcome was defined as dependency (modified Rankin Scale score of 3 to 6) at 3 months from the onset. The predictive values of factors related to an unfavorable outcome were evaluated. External validation was performed from a stroke registry of a tertiary medical center. In the derivation cohort, 3839 consecutive patients were screened; a total of 130 patients were included. Twenty-four (18%) patients had unfavorable outcomes. In multivariate analysis, D-dimer ≥1900 μg/l (odds ratio (OR) 3.31, 95% confidence interval (CI) 1.14–9.61, p  = .028) and age (OR 2.01, 95% CI 1.05–3.86, p  = .035) were independently associated with an unfavorable outcome. No significant differences were observed regarding occluded vessel sites. In the validation cohort, 850 consecutive patients were screened; a total of 74 patients were included. D-dimer ≥1900 μg/l (OR 8.78, 95% CI 1.41–54.61, p  = .020) was the only factor independently associated with an unfavorable outcome, as in the derivation cohort. A high D-dimer level on admission could help predict unfavorable outcomes in patients with a minor ischemic stroke with large vessel occlusion.

Bibliographic Details

Sato, Takeo; Sato, Shoichiro; Yamagami, Hiroshi; Komatsu, Teppei; Mizoguchi, Tadataka; Yoshimoto, Takeshi; Takagi, Masahito; Ihara, Masafumi; Koga, Masatoshi; Iwata, Hiroyoshi; Matsushima, Masato; Toyoda, Kazunori; Iguchi, Yasuyuki

Elsevier BV

Neuroscience; Medicine

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