D-dimer level and outcome of minor ischemic stroke with large vessel occlusion
Journal of the Neurological Sciences, ISSN: 0022-510X, Vol: 413, Page: 116814
2020
- 21Citations
- 27Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations21
- Citation Indexes21
- 21
- CrossRef19
- Captures27
- Readers27
- 27
Article Description
To determine the predictors of unfavorable outcomes in acute minor ischemic stroke patients with large vessel occlusion. The derivation cohort included ischemic stroke patients admitted to a comprehensive stroke center within 7 days after onset with large vessel occlusion and an initial National Institutes of Health Stroke Scale score of 5 or less. An unfavorable outcome was defined as dependency (modified Rankin Scale score of 3 to 6) at 3 months from the onset. The predictive values of factors related to an unfavorable outcome were evaluated. External validation was performed from a stroke registry of a tertiary medical center. In the derivation cohort, 3839 consecutive patients were screened; a total of 130 patients were included. Twenty-four (18%) patients had unfavorable outcomes. In multivariate analysis, D-dimer ≥1900 μg/l (odds ratio (OR) 3.31, 95% confidence interval (CI) 1.14–9.61, p = .028) and age (OR 2.01, 95% CI 1.05–3.86, p = .035) were independently associated with an unfavorable outcome. No significant differences were observed regarding occluded vessel sites. In the validation cohort, 850 consecutive patients were screened; a total of 74 patients were included. D-dimer ≥1900 μg/l (OR 8.78, 95% CI 1.41–54.61, p = .020) was the only factor independently associated with an unfavorable outcome, as in the derivation cohort. A high D-dimer level on admission could help predict unfavorable outcomes in patients with a minor ischemic stroke with large vessel occlusion.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022510X20301507; http://dx.doi.org/10.1016/j.jns.2020.116814; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85082674091&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32259707; https://linkinghub.elsevier.com/retrieve/pii/S0022510X20301507; https://dx.doi.org/10.1016/j.jns.2020.116814
Elsevier BV
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