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Direct comparison of thallium-201 and technetium-99m MIBI SPECT of a glioma by receiver operating characteristic analysis

Journal of Clinical Neuroscience, ISSN: 0967-5868, Vol: 16, Issue: 2, Page: 264-269
2009
  • 10
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    10
    • Citation Indexes
      10
  • Captures
    12

Article Description

The diagnostic value of single photon-emission computed tomography (SPECT) has been assessed using arbitrarily determined sensitivity and specificity cut-off values. The diagnostic accuracy of thallium-201 (Tl-201) SPECT and technetium-99m methoxyisobutylisonitrile (Tc-MIBI) SPECT were compared for patients with primary glioma using receiver operating characteristic (ROC) analysis. The study population included 59 patients with gliomas. Tl and Tc-MIBI SPECT images were obtained using a multi-detector SPECT machine 15 min (early) and 3 hours (delayed) after intravenous injection of 74 MBq of Tl-chloride or 740 MBq of Tc-MIBI. The regions of interest were set on the tumor and contralateral normal white matter and tumor : normal ratios were calculated. The area z-score (A z ) values were calculated from the areas under the ROC curves. All A z values were high and no statistical difference was observed between the two modalities. Both Tl and Tc-MIBI SPECT are useful imaging modalities for the evaluation of glioma malignancy.

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