Voxel-based morphometric study of brain volume changes in patients with Alzheimer’s disease assessed according to the Clinical Dementia Rating score
Journal of Clinical Neuroscience, ISSN: 0967-5868, Vol: 18, Issue: 7, Page: 916-921
2011
- 20Citations
- 29Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations20
- Citation Indexes20
- 20
- CrossRef18
- Captures29
- Readers29
- 29
Article Description
We evaluated the volume reduction of gray matter (GM) and white matter (WM) in patients with an Alzheimer’s disease (AD) assessment based on the Clinical Dementia Rating (CDR) score. Patients with AD ( n = 61), with no subcortical WM ischemia, and healthy control patients ( n = 33) underwent T1-weighted spoiled gradient echo sequences, which were analyzed using voxel-based morphometry. Global GM volume reduction was observed in patients with a CDR score of 1 or a CDR score of 2, and WM volume reduction was observed in patients with a CDR score of 2. Regional GM volume reduction was found in the right inferior frontal gyrus, bilateral dorso-lateral and medial temporal lobes; WM volume reduction was found in the bilateral temporal subcortex (family-wise error, p < 0.01). A CDR score of 0.5 was associated with volume reduction in the left olfactory gyrus. The peak z-score and spatial extent of volume reduction increased with increasing CDR score and were higher on the left side. GM volume reduction increased with increasing CDR scores and suggests a possible pathomechanism of AD.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S096758681100049X; http://dx.doi.org/10.1016/j.jocn.2010.12.019; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79958119310&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21570296; https://linkinghub.elsevier.com/retrieve/pii/S096758681100049X; http://www.jocn-journal.com/article/S0967-5868(11)00049-X/abstract
Elsevier BV
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