Synergistic effect of phototherapy and chemotherapy on bladder cancer cells
Journal of Photochemistry and Photobiology B: Biology, ISSN: 1011-1344, Vol: 193, Page: 148-154
2019
- 8Citations
- 21Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations8
- Citation Indexes8
- CrossRef1
- Captures21
- Readers21
- 21
Article Description
Drug resistance as an important barrier to cancer treatment, has a close relation with alteration of cancer metabolism. Therefore, in this study the synergistic effect of phototherapy and chemotherapy were investigated on the bladder cancer cells viability. The cytotoxicity effect of blue light irradiation was measured by the MTT assay. Glucose consumption, lactate and ammonium formation were analyzed in the blue LED-irradiated cancer cells culture. Also, the expression of some genes involved in apoptosis and epithelial–mesenchymal transition was assessed using real-time PCR in comparison with the control group. The analysis of the results indicated that blue light irradiation inhibited the cell viability in a dose-dependent manner. Blue light irradiation decreased the cell viability by 7% and 19% ( p < .05) in 5637 cells at doses of 8.7 J/cm 2 and 17.5 J/cm 2 in comparison with the control group respectively. Glucose consumption, lactate and ammonium formation diminished in the blue LED-irradiated 5637 cells in both doses. The real time PCR results indicated that the expression of Bax increased in blue light-irradiated cells. In addition, the cell cycle analysis showed that blue light irradiation arrested the bladder cancer in the G1 phase. Also, the effect of combination therapy on cancer cells was investigated in presence of blue light irradiation and cisplatin. The obtained results of the MTT assay indicated that blue light irradiation enhance the cytotoxicity effect of cisplatin on bladder cancer cells.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1011134418313216; http://dx.doi.org/10.1016/j.jphotobiol.2019.02.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85062809792&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/30884284; https://linkinghub.elsevier.com/retrieve/pii/S1011134418313216; https://dx.doi.org/10.1016/j.jphotobiol.2019.02.004
Elsevier BV
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