Synthesis and antifungal activities of novel trifluoroethane derivatives with coumarin, indole and thiophene
Journal of Saudi Chemical Society, ISSN: 1319-6103, Vol: 26, Issue: 6, Page: 101572
2022
- 11Citations
- 9Captures
- 1Mentions
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Most Recent News
Research on Antifungals Described by Researchers at Henan Agricultural University (Synthesis and antifungal activities of novel trifluoroethane derivatives with coumarin, indole and thiophene)
2022 DEC 14 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Investigators publish new report on antifungals. According to news
Article Description
A series of novel 1-(β-coumarinyl)-1-(β-indolyl)-1-(α-thiophenyl)trifluoroethane derivatives 5aaa - 5hdb were prepared by one-pot reaction from 3-(trifluoroacetyl)coumarin with indole and α-substituted thiophene. Their structures were confirmed by 1 H NMR, 13 C NMR, 19 F NMR, HRMS and X-ray single crystal diffraction, and their antifungal activities against F. moniliforme, F. graminearum, F. oxysporum, R. solani and P. nicotianae were evaluated. The title compounds displayed significant to moderate in vitro antifungal activity when compared to the standard drug triadimefon. Among the synthesized compounds, compound 5bfa showed the highest inhibitor rate of 83.5 % at 0.500 mg/mL against R. solani, while compound 5ada displayed the highest inhibitor rate of 73.3 % at 0.500 mg/mL against F. graminearum.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1319610322001545; http://dx.doi.org/10.1016/j.jscs.2022.101572; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85142544810&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S1319610322001545; https://dx.doi.org/10.1016/j.jscs.2022.101572
Springer Science and Business Media LLC
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