Resveratrol supplementation improves metabolic control in rats with induced hyperlipidemia and type 2 diabetes
Saudi Pharmaceutical Journal, ISSN: 1319-0164, Vol: 27, Issue: 7, Page: 1036-1043
2019
- 44Citations
- 82Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations44
- Citation Indexes44
- 44
- CrossRef37
- Captures82
- Readers82
- 82
Article Description
Resveratrol was recognized as the major factor responsible for the beneficial properties of red wine. Several resveratrol-based dietary supplements are available, but their efficacy has not been sufficiently tested. This study was designed to examine the effect of resveratrol supplementation, using a commercially available product, on the metabolic status of experimental animals with induced hyperlipidemia or type 2 diabetes mellitus (T2DM). Hyperlipidemia was induced by feeding the rats a standard pellet diet supplemented with cholesterol. T2DM was induced by adding 10% fructose to drinking water and streptozotocin. Treatment with resveratrol-based supplement improved glycemic control in diabetic animals and significantly decreased serum low-density-lipoprotein (LDL) and triglyceride levels, concurrently increasing the high-density-lipoprotein (HDL) levels in animals with hyperlipidemia. Resveratrol-treated animals had improved tolerance to glucose loading. Supplementation did not induce alterations in parameters of liver and renal function. Findings indicate that commercial resveratrol supplement improves metabolic control in rats with induced hyperlipidemia and T2DM.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1319016419301148; http://dx.doi.org/10.1016/j.jsps.2019.08.006; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85071844493&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/31997911; https://linkinghub.elsevier.com/retrieve/pii/S1319016419301148; https://dx.doi.org/10.1016/j.jsps.2019.08.006
Springer Science and Business Media LLC
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