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Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15 haplotypes

Journal of Surgical Research, ISSN: 0022-4804, Vol: 214, Page: 262-269
2017
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Metric Options:   Counts1 Year3 Year

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Article Description

Diverticulitis (DD) and Crohn's disease (CD) have overlapping features including bowel structuring, inflammation, and infection. Tumor necrosis superfamily 15 (TNFSF15) is an immunoregulatory, anti-angiogenic gene. CD has been previously associated with a haplotype of five TNFSF15 single-nucleotide polymorphism alleles: rs3810936 (G allele), rs6478108 (A), rs6478109 (G), rs7848647 (G), and rs7869487 (A). We aimed to determine the TNFSF15 risk haplotype for DD versus controls with a subgroup analysis of youthful DD patients (aged ≤55 y) versus older controls (aged ≥55 y).

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