Down-regulated reactive oxygen species by HSP90 in 3HK-induced SKN-SH cell death
Journal of Thermal Biology, ISSN: 0306-4565, Vol: 30, Issue: 1, Page: 43-49
2005
- 5Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
In this present study, we show that 3HK induced reactive oxygen species (ROS) accumulation and after caspase activation lead to apoptotic cell death. Pretreatment with N -acetylcysteine (NAC), an effective antioxidant, significantly attenuated 3HK-induced apoptosis by way of a reduction of ROS accumulation and caspase activity. SKN-SN cells were protected from 3HK-induced cytotoxicity by heat shock protein (HSP). HSP effectively attenuated 3HK-mediated ROS accumulation and apoptosis. In addition, the protective effect of HSP90 was abolished by pretreatment with HSP90 anti-sense oligonucleotides, but not when pretreated with anti-senses for other HSPs. These results suggest that HSP90 protects SKN-SH cells from 3HK-induced cytotoxicity by reducing ROS levels and caspase activity.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0306456504000592; http://dx.doi.org/10.1016/j.jtherbio.2004.06.005; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=9244234366&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0306456504000592; https://api.elsevier.com/content/article/PII:S0306456504000592?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S0306456504000592?httpAccept=text/plain; https://dx.doi.org/10.1016/j.jtherbio.2004.06.005
Elsevier BV
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