Challenges and Strategies for Regenerating the Lacrimal Gland
The Ocular Surface, ISSN: 1542-0124, Vol: 14, Issue: 2, Page: 135-143
2016
- 20Citations
- 18Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations20
- Citation Indexes20
- 20
- CrossRef9
- Captures18
- Readers18
- 18
Review Description
The lacrimal gland produces the aqueous component of tears, including electrolytes, peptides, and glycoproteins necessary to maintain homeostasis and optical properties of the ocular surface. Stem cells that contribute to the homeostasis of the lacrimal gland are under extensive study. It is still unclear whether such stem cells are of mesenchymal or epithelial origin. It is also possible that a unique epithelial stem cell undergoes epithelial-mesenchymal transition and contributes to the mesenchyme. Developmental studies in mice have shown that a network of growth factors contributes to epithelial-mesenchymal interaction during morphogenesis of the lacrimal gland. Recently, the developmental process was successfully recapitulated in vitro, providing a valuable tool for study of lacrimal gland development and possibly opening doors to regenerative therapy. While further studies are required to identify and appreciate the potential of lacrimal gland stem cells, advances in stem cell biology in general should become a catalyst towards developing regenerative therapy of the lacrimal gland.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1542012415002086; http://dx.doi.org/10.1016/j.jtos.2015.11.005; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84963961071&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/26738799; https://linkinghub.elsevier.com/retrieve/pii/S1542012415002086
Elsevier BV
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