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In Utero Exposure to Benzophenone-2 Causes Hypospadias Through an Estrogen Receptor Dependent Mechanism

The Journal of Urology, ISSN: 0022-5347, Vol: 178, Issue: 4, Page: 1637-1642
2007
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Article Description

Additives such as benzophenone-2 are commonly used in cosmetic products and food container plastics to filter out ultraviolet light. In pregnant women exposure may result in transplacental transfer of benzophenone-2 to fetuses. Benzophenone-2 is estrogenic in vitro and in the rat uterotropic assay. Estradiol causes hypospadias in mice and estrogen-like compounds are also postulated to cause hypospadias. We determined whether hypospadias would develop in male mice exposed to benzophenone-2 in utero and whether this outcome depended on estrogen receptor pathways.

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