Transcriptional landscape of TRPV1 , TRPA1 , TRPV4 , and TRPM8 channels throughout human tissues
Life Sciences, ISSN: 0024-3205, Vol: 308, Page: 120977
2022
- 8Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations8
- Citation Indexes8
- CrossRef5
- Captures24
- Readers24
- 24
Article Description
This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset from the National Center for Biotechnology Information (NCBI) gene database, we investigated and compared the transcriptional levels of TRPV1, TRPA1, TRPV4 and TRPM8 found in 95 human subjects representing 33 different tissues to determine the tissue specificity of all protein-coding genes. In this study, we observed higher transcriptional levels for TRPV1 (duodenum), TRPA1 (Urinary bladder), TRPV4 (Kidney) and TRPM8 (Prostate) compared to the other TRPs. These channels are involved in developing inflammatory and painful pathologies and seem to participate in cancer development. This information on transcriptional levels of TRPV1, TRPA1, TRPV4 and TRPM8 in human systems may provide essential suggestions for further studies on these proteins.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0024320522006774; http://dx.doi.org/10.1016/j.lfs.2022.120977; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85138209115&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36126722; https://linkinghub.elsevier.com/retrieve/pii/S0024320522006774; https://dx.doi.org/10.1016/j.lfs.2022.120977
Elsevier BV
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