Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis
Mechanisms of Ageing and Development, ISSN: 0047-6374, Vol: 157, Page: 17-29
2016
- 75Citations
- 70Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations75
- Citation Indexes75
- 75
- CrossRef51
- Captures70
- Readers70
- 70
- Mentions1
- Blog Mentions1
- 1
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Introduction Thus, it is necessary to elucidate the overall processes and signaling pathways of NAFLD and the mechanisms associated with its treatment. Isobaric Tags for Relative and Absolute Quantification (iTRAQ) is a novel technique developed by Applied Biosystems Incorporation (ABI) with many advantages, such as high throughput, high sensitivity, and superior accuracy, and has grown to be a ro
Review Description
Nonalcoholic steatohepatitis (NASH) is considered to be a common health problem since the incidence of nonalcoholic fatty liver disease (NAFLD) has increased in recent years. Disturbed hepatic cholesterol homeostasis and free cholesterol accumulation in liver results in increased oxidative stress leading to the endoplasmic reticulum (ER) stress. Activated ER stress maintains protein homeostasis however, delayed or inadequate ER stress responses may induce fat accumulation, insulin resistance, inflammation, apoptosis, and autophagy, all of which increase with age and play crucial roles in the pathogenesis of NASH. In aging research, there is a growing interest for the role of ER stress in the progression of NASH since aging seems to favor NAFLD according to its pathogenesis. On the other hand, specific microRNAs (miRNAs) expression profiles are strongly related with ER stress as well as NASH progresses. This review highlights molecular mechanisms related to ER stress in the pathogenesis of NASH and miRNAs for the progression and treatment of the disease.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0047637416301026; http://dx.doi.org/10.1016/j.mad.2016.07.001; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84978763686&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27393639; https://linkinghub.elsevier.com/retrieve/pii/S0047637416301026; https://dx.doi.org/10.1016/j.mad.2016.07.001
Elsevier BV
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