Preparation and characterization of thermosensitive hydrogel system for dual sustained-release of chlorhexidine and bovine serum albumin
Materials Letters, ISSN: 0167-577X, Vol: 300, Page: 130121
2021
- 9Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Chlorhexidine (CHX)/β-cyclodextrin (β-CD) inclusion and chitosan nanoparticles containing bovine serum albumin (CS/BSA) were blended into chitosan acetic acid solution respectively or simultaneously to prepare a novel thermosensitive hydrogel dual sustained-release system. Rheological properties, release, cytocompatibility, and antibacterial activity were investigated. The results confirmed that CHX/β-CD and CS/BSA were well dispersed in the solution, and the rheological property of hydrogel was not affected. The system exhibited promising dual sustained release and cytocompatibility. Antibacterial results showed that CHX-loaded hydrogel had a desirable therapeutic effect on Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli).
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0167577X21008181; http://dx.doi.org/10.1016/j.matlet.2021.130121; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85107550112&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0167577X21008181; https://dx.doi.org/10.1016/j.matlet.2021.130121
Elsevier BV
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