Mammary cell-activating factor regulates the hormone-independent transcription of the early lactation protein ( ELP ) gene in a marsupial
Molecular and Cellular Endocrinology, ISSN: 0303-7207, Vol: 436, Page: 169-182
2016
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Article Description
The regulation of the tammar wallaby ( Macropus eugenii ) early lactation protein ( ELP ) gene is complex. ELP is responsive to the lactogenic hormones; insulin (I), hydrocortisone (HC) and prolactin (PRL) in mammary gland explants but could not be induced with lactogenic hormones in tammar primary mammary gland cells, nor in KIM-2 conditionally immortalised murine mammary epithelial cells. Similarly, ELP promoter constructs transiently-transfected into human embryonic kidney (HEK293T) cells constitutively expressing the prolactin receptor (PRLR) and Signal Transducer and Activator of Transcription (STAT)5A were unresponsive to prolactin, unlike the rat and mouse β-casein ( CSN2 ) promoter constructs. Identification of the minimal promoter required for the hormone-independent transcription of tammar ELP in HEK293Ts and comparative analysis of the proximal promoters of marsupial ELP and the orthologous eutherian colostrum trypsin inhibitor ( CTI ) gene suggests that mammary cell-activating factor (MAF), an E26 transformation-specific (ETS) factor, may bind to an AGGAAG motif and activate tammar ELP.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0303720716302635; http://dx.doi.org/10.1016/j.mce.2016.07.023; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84984861513&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27452799; https://linkinghub.elsevier.com/retrieve/pii/S0303720716302635; https://dx.doi.org/10.1016/j.mce.2016.07.023
Elsevier BV
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