AMPK inhibits voltage-gated calcium channel-current in rat chromaffin cells
Molecular and Cellular Endocrinology, ISSN: 0303-7207, Vol: 591, Page: 112275
2024
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Article Description
Metabolic changes are critical in the regulation of Ca 2+ influx in central and peripheral neuroendocrine cells. To study the regulation of L-type Ca 2+ channels by AMPK we used biochemical reagents and ATP/glucose-concentration manipulations in rat chromaffin cells. AICAR and Compound-C, at low concentration, significantly induce changes in L-type Ca 2+ channel-current amplitude and voltage dependence. Remarkably, an overlasting decrease in the channel-current density can be induced by lowering the intracellular level of ATP. Accordingly, Ca 2+ channel-current density gradually diminishes by decreasing the extracellular glucose concentration. By using immunofluorescence, a decrease in the expression of Ca V 1.2 is observed while decreasing extracellular glucose, suggesting that AMPK reduces the number of functional Ca 2+ channels into the plasma membrane. Together, these results support for the first time the dependence of metabolic changes in the maintenance of Ca 2+ channel-current by AMPK. They reveal a key step in Ca 2+ influx in secretory cells.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S030372072400131X; http://dx.doi.org/10.1016/j.mce.2024.112275; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85193826010&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38777212; https://linkinghub.elsevier.com/retrieve/pii/S030372072400131X; https://dx.doi.org/10.1016/j.mce.2024.112275
Elsevier BV
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