A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis
Med, ISSN: 2666-6340, Vol: 2, Issue: 9, Page: 1072-1092.e7
2021
- 49Citations
- 86Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations49
- Citation Indexes48
- 48
- CrossRef11
- Patent Family Citations1
- Patent Families1
- Captures86
- Readers86
- 86
- Mentions1
- News Mentions1
- News1
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Difficulties in diagnosis of SARS-CoV-2 myocarditis in an adolescent
OBJECTIVES: We present an adolescent with cardiogenic shock due to ventricular tachycardia 2 weeks after SARS-CoV-2 infection. Acute myocarditis or myocardial dysfunction is associated with
Article Description
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children is generally milder than in adults, but a proportion of cases result in hyperinflammatory conditions often including myocarditis. To better understand these cases, we applied a multiparametric approach to the study of blood cells of 56 children hospitalized with suspicion of SARS-CoV-2 infection. Plasma cytokine and chemokine levels and blood cellular composition were measured, alongside gene expression at the bulk and single-cell levels. The most severe forms of multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 that resulted in myocarditis were characterized by elevated levels of pro-angiogenesis cytokines and several chemokines. Single-cell transcriptomics analyses identified a unique monocyte/dendritic cell gene signature that correlated with the occurrence of severe myocarditis characterized by sustained nuclear factor κB (NF-κB) activity and tumor necrosis factor alpha (TNF-α) signaling and associated with decreased gene expression of NF-κB inhibitors. We also found a weak response to type I and type II interferons, hyperinflammation, and response to oxidative stress related to increased HIF-1α and Vascular endothelial growth factor (VEGF) signaling. These results provide potential for a better understanding of disease pathophysiology. Agence National de la Recherche (Institut Hospitalo-Universitaire Imagine, grant ANR-10-IAHU-01; Recherche Hospitalo-Universitaire, grant ANR-18-RHUS-0010; Laboratoire d’Excellence ‘‘Milieu Intérieur,” grant ANR-10-LABX-69-01; ANR-flash Covid19 “AIROCovid” and “CoVarImm”), Institut National de la Santé et de la Recherche Médicale (INSERM), and the “URGENCE COVID-19” fundraising campaign of Institut Pasteur.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S2666634021002877; http://dx.doi.org/10.1016/j.medj.2021.08.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85118967985&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34414385; https://linkinghub.elsevier.com/retrieve/pii/S2666634021002877; https://dx.doi.org/10.1016/j.medj.2021.08.002; https://www.cell.com/med/fulltext/S2666-6340(21)00287-7#relatedArticles; http://www.cell.com/article/S2666634021002877/abstract; http://www.cell.com/article/S2666634021002877/fulltext; http://www.cell.com/article/S2666634021002877/pdf; https://www.cell.com/med/abstract/S2666-6340(21)00287-7; https://www.cell.com/med/fulltext/S2666-6340(21)00287-7; https://www.cell.com/med/fulltext/S2666-6340(21)00287-7#.YRu828hNSoo.twitter; https://www.cell.com/med/fulltext/S2666-6340(21)00287-7#.YTtxPrzjG5Q.twitter; https://www.cell.com/med/fulltext/S2666-6340(21)00287-7#.YRq4P9QRhJg.twitter
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