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A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis

Med, ISSN: 2666-6340, Vol: 2, Issue: 9, Page: 1072-1092.e7
2021
  • 49
    Citations
  • 0
    Usage
  • 86
    Captures
  • 1
    Mentions
  • 3
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    49
  • Captures
    86
  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    3
    • Shares, Likes & Comments
      3
      • Facebook
        3

Most Recent News

Difficulties in diagnosis of SARS-CoV-2 myocarditis in an adolescent

OBJECTIVES: We present an adolescent with cardiogenic shock due to ventricular tachycardia 2 weeks after SARS-CoV-2 infection. Acute myocarditis or myocardial dysfunction is associated with

Article Description

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children is generally milder than in adults, but a proportion of cases result in hyperinflammatory conditions often including myocarditis. To better understand these cases, we applied a multiparametric approach to the study of blood cells of 56 children hospitalized with suspicion of SARS-CoV-2 infection. Plasma cytokine and chemokine levels and blood cellular composition were measured, alongside gene expression at the bulk and single-cell levels. The most severe forms of multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 that resulted in myocarditis were characterized by elevated levels of pro-angiogenesis cytokines and several chemokines. Single-cell transcriptomics analyses identified a unique monocyte/dendritic cell gene signature that correlated with the occurrence of severe myocarditis characterized by sustained nuclear factor κB (NF-κB) activity and tumor necrosis factor alpha (TNF-α) signaling and associated with decreased gene expression of NF-κB inhibitors. We also found a weak response to type I and type II interferons, hyperinflammation, and response to oxidative stress related to increased HIF-1α and Vascular endothelial growth factor (VEGF) signaling. These results provide potential for a better understanding of disease pathophysiology. Agence National de la Recherche (Institut Hospitalo-Universitaire Imagine, grant ANR-10-IAHU-01; Recherche Hospitalo-Universitaire, grant ANR-18-RHUS-0010; Laboratoire d’Excellence ‘‘Milieu Intérieur,” grant ANR-10-LABX-69-01; ANR-flash Covid19 “AIROCovid” and “CoVarImm”), Institut National de la Santé et de la Recherche Médicale (INSERM), and the “URGENCE COVID-19” fundraising campaign of Institut Pasteur.

Bibliographic Details

de Cevins, Camille; Luka, Marine; Smith, Nikaïa; Meynier, Sonia; Magérus, Aude; Carbone, Francesco; García-Paredes, Víctor; Barnabei, Laura; Batignes, Maxime; Boullé, Alexandre; Stolzenberg, Marie-Claude; Pérot, Brieuc P; Charbit, Bruno; Fali, Tinhinane; Pirabakaran, Vithura; Sorin, Boris; Riller, Quentin; Abdessalem, Ghaith; Beretta, Maxime; Grzelak, Ludivine; Goncalves, Pedro; Di Santo, James P; Mouquet, Hugo; Schwartz, Olivier; Zarhrate, Mohammed; Parisot, Mélanie; Bole-Feysot, Christine; Masson, Cécile; Cagnard, Nicolas; Corneau, Aurélien; Brunaud, Camille; Zhang, Shen-Ying; Casanova, Jean-Laurent; Bader-Meunier, Brigitte; Haroche, Julien; Melki, Isabelle; Lorrot, Mathie; Oualha, Mehdi; Moulin, Florence; Bonnet, Damien; Belhadjer, Zahra; Leruez, Marianne; Allali, Slimane; Gras-Leguen, Christèle; de Pontual, Loïc; Pediatric-Biocovid Study Group; Fischer, Alain; Duffy, Darragh; Rieux-Laucat, Fredéric; Toubiana, Julie; Ménager, Mickaël M

Elsevier BV

Medicine

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