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Characteristics of the mosaic genome of a human parechovirus type 1 strain isolated from an infant with pneumonia in China

Infection, Genetics and Evolution, ISSN: 1567-1348, Vol: 29, Page: 91-98
2015
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Article Description

Human parechoviruses (HPeVs) belong to the Parechovirus genus of the large and growing family of Picornaviridae with a non-enveloped, single-stranded and positive-sense RNA. An HPeV strain was isolated from the nasopharyngeal aspirate specimen of a 2 months old infant hospitalized with pneumonia in Beijing, China and nominated as BJ-37359 followed the code of the specimen. Strain BJ-37359 was identified as HPeV1 by whole genome sequencing. The full genome of strain BJ-37359 consisted of 7336 nucleotides (nt), excluding a poly (A) tail and contained an ORF of 6537 nt flanked by 5′UTR of 709 nt and 3′UTR of 90 nt. Phylogenetic analyses revealed that strain BJ-37359 were clustered together with HPeV1 strains in the structural capsid protein region, while uncoupling in the non-structural gene regions. Analyses with Simplot and Bootscan indicated that multiple recombination events occurred in the non-structural region and VP0 region of strain BJ-37359 with other HPeV1, and other types might have contributed to the recombination, especially HPeV6 and HPeV7 strains. Recombination analyses indicated that strain BJ-37359 may have a mosaic genome with new genomic recombination breakpoints.

Bibliographic Details

Zhu, Runan; Luo, Lei; Zhao, Linqing; Deng, Jie; Wang, Fang; Sun, Yu; Song, Qinwei; Ding, Yaxin; Qian, Yuan

Elsevier BV

Immunology and Microbiology; Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine

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