Transient immunosuppression during short interruption of HAART: Another key to HIV cure in the “Berlin patient”?
Medical Hypotheses, ISSN: 0306-9877, Vol: 123, Page: 6-8
2019
- 12Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Captures12
- Readers12
- 12
Article Description
Transient immunosuppression in lentiviral infections leads to an auto-vaccination followed by the rise of serum neutralizing activity and a significant decrease in a set-point viral load, which becomes undetectable in some cases. Arguably, in the “Berlin patient” (Hütter G, et al., N Engl J Med, 2009) an induction chemotherapy-mediated transient immunosuppression episode during short interruption of HAART might have led to at least a “functional cure” before allogeneic stem cell transplantation. Neutralization-enhancing RF antibodies (NeRFa) induced as a part of secondary immune response after transient immunosuppression may have played a key role in neutralization of infectious HIV-IgG complexes in extracellular reservoirs. Transient immunosuppression during short non-structured treatment interruption (TI-SNSTI/HAART) regimen would be promising for the achievement of HIV cure on a large scale.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0306987718310296; http://dx.doi.org/10.1016/j.mehy.2018.12.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85058049354&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/30696593; https://linkinghub.elsevier.com/retrieve/pii/S0306987718310296; https://dx.doi.org/10.1016/j.mehy.2018.12.002
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know