PlumX Metrics
Embed PlumX Metrics

New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.1 3,11 ]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system

Mendeleev Communications, ISSN: 0959-9436, Vol: 33, Issue: 1, Page: 70-72
2023
  • 4
    Citations
  • 0
    Usage
  • 1
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

An optimized synthesis of N -{5-[(1,11-dimethyl-4,8,12-trioxo-3,6,9-triazatricyclo[7.3.1.1 3,11 ]tetradec-6-yl)methyl]-indan-2-yl}-1,3-benzodioxole-5-carboxamide has been carried out from indan-2-one oxime in seven steps. In vitro studies using electrophysiological patch clamp technique have revealed a positive modulation effect of this compound on kainate induced currents in Purkinje neurons in a wide range of concentrations from 10 –12 to 10 –8 m.

Bibliographic Details

Elena A. Golubeva; Mstislav I. Lavrov; Polina N. Veremeeva; Evgenia M. Bovina; Eugene V. Radchenko; Maxim A. Topchiy; Andrey F. Asachenko; Vladimir L. Zamoyski; Vladimir V. Grigoriev; Vladimir A. Palyulin

OOO Zhurnal "Mendeleevskie Soobshcheniya"

Chemistry

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know