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Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms

Current Opinion in Microbiology, ISSN: 1369-5274, Vol: 53, Page: 51-60
2020
  • 208
    Citations
  • 0
    Usage
  • 627
    Captures
  • 3
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    208
  • Captures
    627
  • Mentions
    3
    • News Mentions
      2
      • 2
    • References
      1
      • 1

Most Recent News

Sequential Therapy of Linezolid and Contezolid to Treat Hematogenous Lung Abscess Caused by Staphylococcus aureus in a Congenital Cerebral Hypoplasia Patient: A Case Report

Introduction Hematogenous lung abscesses are primarily caused by pathogens from extrapulmonary sources that spread to the lungs through the bloodstream, leading to small vessel embolism,

Review Description

Staphylococcus aureus is an opportunistic pathogen that normally colonizes the human anterior nares. At the same time, this pathogen is one of the leading causes of life-threatening bloodstream infections, such as sepsis and endocarditis. In this review we will present the current understanding of the pathogenesis of these invasive infections, focusing on the mechanisms of S. aureus clearance from the bloodstream by the immune system, and how this pathogen hijacks the host defense and coagulation systems and further interacts with the blood vessel endothelium. Additionally, we will delve into the regulatory mechanisms S. aureus employs during an invasive infection. These new insights into host–pathogen interactions show promising avenues for the development of novel therapies for treating bloodstream infections.

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