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An unusual murine behavior following infection with log-phase Nocardia asteroides type 6 strain GUH-2 ( Nocardia cyriacigeorgica GUH-2)

Microbes and Infection, ISSN: 1286-4579, Vol: 10, Issue: 7, Page: 840-843
2008
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Article Description

Nocardia asteroides ( Nocardia cyriacigeorgica ) strain GUH-2 infects the brains of mice following intravenous injection. Non-lethal infections resulted in a transitory increase of bacterial numbers in the brain followed by the development of permanent impaired movements at a time when bacteria appeared to be eliminated from the brain. These signs included headshake, rigidity, stooped posture, dyskinesia, retropulsion, and abnormal tail positioning in approximately 20% of infected animals. The attached video presents a typical mouse following infection with this organism, as compared to an age- and gender-matched uninfected control mouse.

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