Efficient and rapid synthesis of ultrathin nickel-metal organic framework nanosheets for the sensitive determination of glucose

Ultrathin metal–organic frameworks (MOFs) have been traditionally synthesized by time-consuming hydrothermal or sonication procedures, thereby hampering the cost-effectiveness and widespread applicability. This study introduces an efficient and rapid one-pot synthesis route to ultrathin nickel-metal organic framework (Ni-MOFNs) of nanosheet architecture. The synthesized MOF was characterized using XRD, XPS, Raman spectroscopy, AFM, and FE-TEM analysis. The MOF was successfully applied for the sensitive determination of glucose under alkaline conditions. The non-enzymatic glucose sensor reported in this work offers superior analytical performances with a wide linear range (25–3150 μM), a low detection limit (0.6 µM), and high sensitivity (0.4023 mAmM -1 cm −2 ). Moreover, it can also be applied for the determination of glucose in human blood serum with the relative standard deviation (RSD) of 1.3–4.2%, showing the high precision of the sensor in practical applications. This study opens a new rapid synthesis route to ultrathin Ni-MOF, which will supplement the established synthesis routes of Ni-MOF for sensor and electronic applications.