Neuroimaging of mitochondrial disease
Mitochondrion, ISSN: 1567-7249, Vol: 8, Issue: 5, Page: 396-413
2008
- 191Citations
- 160Captures
- 2Mentions
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Metrics Details
- Citations191
- Citation Indexes191
- 191
- CrossRef168
- Captures160
- Readers160
- 160
- Mentions2
- References2
- Wikipedia2
Review Description
Mitochondrial disease represents a heterogeneous group of genetic disorders that require a variety of diagnostic tests for proper determination. Neuroimaging may play a significant role in diagnosis. The various modalities of nuclear magnetic resonance imaging (MRI) allow for multiple independent detection procedures that can give important anatomical and metabolic clues for diagnosis. The non-invasive nature of neuroimaging also allows for longitudinal studies. To date, no pathonmonic correlation between specific genetic defect and neuroimaging findings have been described. However, certain neuroimaging results can give important clues that a patient may have a mitochondrial disease. Conventional MRI may show deep gray structural abnormalities or stroke-like lesions that do not respect vascular territories. Chemical techniques such as proton magnetic resonance spectroscopy (MRS) may demonstrate high levels of lactate or succinate. When found, these results are suggestive of a mitochondrial disease. MRI and MRS studies may also show non-specific findings such as delayed myelination or non-specific leukodystrophy picture. However, in the context of other biochemical, structural, and clinical findings, even non-specific findings may support further diagnostic testing for potential mitochondrial disease. Once a diagnosis has been established, these non-invasive tools can also aid in following disease progression and evaluate the effects of therapeutic interventions.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1567724908000378; http://dx.doi.org/10.1016/j.mito.2008.05.003; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=54949094371&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/18590986; https://linkinghub.elsevier.com/retrieve/pii/S1567724908000378
Elsevier BV
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