Mitochondrial dysfunction in cognitive neurodevelopmental disorders: Cause or effect?
Mitochondrion, ISSN: 1567-7249, Vol: 69, Page: 18-32
2023
- 14Citations
- 44Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations14
- Citation Indexes14
- 14
- CrossRef10
- Captures44
- Readers44
- 44
Review Description
Mitochondria have a crucial role in brain development and neurogenesis, both in embryonic and adult brains. Since the brain is the highest energy consuming organ, it is highly vulnerable to mitochondrial dysfunction. This has been implicated in a range of brain disorders including, neurodevelopmental conditions, psychiatric illnesses, and neurodegenerative diseases. Genetic variations in mitochondrial DNA (mtDNA), and nuclear DNA encoding mitochondrial proteins, have been associated with several cognitive disorders. However, it is not yet clear whether mitochondrial dysfunction is a primary cause of these conditions or a secondary effect. Our review article deals with this topic, and brings out recent advances in mitochondria-oriented therapies. Mitochondrial dysfunction could be involved in the pathogenesis of a subset of disorders involving cognitive impairment. In these patients, mitochondrial dysfunction could be the cause of the condition, rather than the consequence. There are vast areas in this topic that remains to be explored and elucidated.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1567724923000028; http://dx.doi.org/10.1016/j.mito.2023.01.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85146269990&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36621534; https://linkinghub.elsevier.com/retrieve/pii/S1567724923000028; https://dx.doi.org/10.1016/j.mito.2023.01.002
Elsevier BV
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