PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop
Molecular Cell, ISSN: 1097-2765, Vol: 32, Issue: 6, Page: 803-814
2008
- 216Citations
- 173Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations216
- Citation Indexes216
- 216
- CrossRef195
- Captures173
- Readers173
- 173
- Mentions1
- Blog Mentions1
- Blog1
Article Description
p73 has been identified as a structural and functional homolog of the tumor suppressor p53. The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to interact with and to enhance p73-dependent apoptosis in response to DNA damage. Here, we show the existence of a proapoptotic autoregulatory feedback loop between p73, YAP, and the promyelocytic leukemia (PML) tumor suppressor gene. We demonstrate that PML is a direct transcriptional target of p73/YAP, and we show that PML transcriptional activation by p73/YAP is under the negative control of the proto-oncogenic Akt/PKB kinase. Importantly, we find that PML and YAP physically interact through their PVPVY and WW domains, respectively, causing PML-mediated sumoylation and stabilization of YAP. Hence, we determine a mechanistic pathway in response to DNA damage that could have relevant implications for the treatment of human cancer.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1097276508008411; http://dx.doi.org/10.1016/j.molcel.2008.11.019; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=57749084642&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/19111660; https://linkinghub.elsevier.com/retrieve/pii/S1097276508008411; https://dx.doi.org/10.1016/j.molcel.2008.11.019
Elsevier BV
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