Mutation Rate Heterogeneity Increases Odds of Survival in Unpredictable Environments
Molecular Cell, ISSN: 1097-2765, Vol: 75, Issue: 3, Page: 421-425
2019
- 31Citations
- 90Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations31
- Citation Indexes31
- 31
- CrossRef3
- Captures90
- Readers90
- 90
Review Description
Mutation rates affect both a population’s present fitness and its capacity to adapt to future environmental changes. When the available genetic variability limits adaptation to environmental change, natural selection favors high mutations rates. However, constitutively high mutation rates compromise the fitness of a population in stable environments. This problem may be resolved if an increase in mutation rates is limited to times of stress, restricted to some genomic regions, and occurs only in a subpopulation of cells. Such within-population heterogeneity of mutation rates can result from genetic, environmental, and stochastic effects. The presence of subpopulations of transient mutator cells does not jeopardize the overall fitness of a population under stable environmental conditions. However, they can increase the odds of survival in changing environments because they represent reservoirs of increased genetic variability. This article presents evidence that such heterogeneity of mutation rates is more the norm than the exception.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1097276519304861; http://dx.doi.org/10.1016/j.molcel.2019.06.029; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85068483507&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/31398322; https://linkinghub.elsevier.com/retrieve/pii/S1097276519304861; https://dx.doi.org/10.1016/j.molcel.2019.06.029
Elsevier BV
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