Effect of solute aggregation on solubilization
Journal of Molecular Liquids, ISSN: 0167-7322, Vol: 274, Page: 209-214
2019
- 10Citations
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Strong self-association of hydrophobic solutes takes place in water. However, solute self-association has often been neglected in understanding the aqueous solubility of drugs as well as their solubilization by excipients, cosolvents and hydrotropes. Based on a rigorous statistical thermodynamic foundation, here we show how to estimate the contribution from solute self-association to solubility and solubilization, based on experimental data such as solubility and the osmotic second virial coefficients. Such data show that solute self-association can indeed be negligible in most common cases of hydrotropic solubilization, Setschenow coefficients and the hydrophobic hydration.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0167732218337395; http://dx.doi.org/10.1016/j.molliq.2018.10.102; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85056161837&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0167732218337395; https://dx.doi.org/10.1016/j.molliq.2018.10.102
Elsevier BV
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