Antibiotic amphotericin B–DPPC lipid complex: X-ray diffraction and FTIR studies
Journal of Molecular Structure, ISSN: 0022-2860, Vol: 1080, Page: 57-62
2015
- 10Citations
- 19Captures
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Article Description
In this work, we studied the formation of a complex between the polyene antibiotic amphotericin B (AmB) and dipalmitoylphosphatidylcholine (DPPC) lipid multibilayers by means of X-ray diffraction and FTIR spectroscopy. The complex formation can be detected in multibilayers by characteristic reflection around 2.2 Å −1. The FTIR spectra indicate that in this case AmB lowers the main phase transition of DPPC. Additionally, with an increase in temperature, a shift of AmB towards the hydrophilic part of the DPPC bilayer is observed. For the first time, such complex formation has been observed by X-ray diffraction and discussed.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022286014009909; http://dx.doi.org/10.1016/j.molstruc.2014.09.076; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84908388221&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0022286014009909; https://dul.usage.elsevier.com/doi/; https://api.elsevier.com/content/article/PII:S0022286014009909?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S0022286014009909?httpAccept=text/plain; https://dx.doi.org/10.1016/j.molstruc.2014.09.076
Elsevier BV
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