Silica-coated magnetic nanoparticles containing bis dicationic bridge for the synthesis of 1,2,4-triazolo pyrimidine/ quinazolinone derivatives

In this work and for the first time, the preparation of bis-[(3-aminopropyl)triethoxysilane]dichloride immobilized on magnetic nano γ -Fe 2 O 3 @SiO 2 via the reaction of two molecules of 3-aminopropyl)triethoxysilane with 1,4-dichlorobutane followed by immobilization of the resulted di-cationic compound on silica-coated nano γ-Fe 2 O 3 is reported. After characterization using FT-IR, XRD, FE-SEM and TGA techniques, the prepared reagent was used for the efficient promotion of the synthesis of 1,2,4-triazolopyrimidine/quinazolinone derivatives with excellent rates and yields. The recovery and reusability of the catalyst were also studied for both of the reactions using an external magnet.