Microwave assists synthesis of spirothiazolidine derivatives to induce cervical cancer cell death-mediated apoptosis in vitro
Journal of Molecular Structure, ISSN: 0022-2860, Vol: 1294, Page: 136424
2023
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Most Recent News
Findings from National Research Centre in the Area of Cervical Cancer Described (Microwave Assists Synthesis of Spirothiazolidine Derivatives To Induce Cervical Cancer Cell Death-mediated Apoptosis In Vitro)
2023 DEC 15 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Women's Health Daily -- Data detailed on Oncology - Cervical Cancer have
Article Description
Herein, a new series of spirothiazolidine derivatives 1–14 are effectively produced using microwave irradiation in a quick and efficient manner. IR, NMR, and mass spectra were used to characterize all new formed substances. Newly created substances based on spirothiazolidinone ring system were tested for their anticancer effects on the common human cervical cancer cell lines HEp-2 and HeLa to produce effective initiative anti-cervical cancer analogs in order to complement or replace the existing anti-cervical cancer chemicals. Among the suggested compounds, compounds 7, 9d, 12, and 13 were found to be the most effective. In HeLa and HEp-2 cells, compounds 7 and 13 significantly increased the expression of CAS3 and Bax while significantly decreasing the expression of KRAS, NRAS, and Bcl-2. We are able to conclude that Compounds 7 and 13 inhibited the RAS gene in order to cause apoptosis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022286023015144; http://dx.doi.org/10.1016/j.molstruc.2023.136424; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85169795368&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0022286023015144; https://dx.doi.org/10.1016/j.molstruc.2023.136424
Elsevier BV
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