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The application of B1 inhomogeneity-corrected variable flip angle T1 mapping for assessing liver fibrosis

Magnetic Resonance Imaging, ISSN: 0730-725X, Vol: 113, Page: 110215
2024
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  • 3
    Captures
  • 1
    Mentions
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    Social Media
Metric Options:   Counts1 Year3 Year

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  • Captures
    3
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Data on Liver Fibrosis Detailed by Researchers at Lanzhou University (The Application of B1 Inhomogeneity-corrected Variable Flip Angle T1 Mapping for Assessing Liver Fibrosis)

2024 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Daily News -- New research on Liver Diseases and Conditions - Liver

Article Description

The aim of this study was to evaluate the diagnostic accuracy of the B1 inhomogeneity-corrected variable flip angle (VFA) method using native T1 values in the staging of liver fibrosis. Eighty-three patients who presented for liver biopsy due to varying degrees of liver damage, underwent MR examinations and had T1-mapping images of the liver acquired using the B1 inhomogeneity-corrected VFA VIBE method. Among them, 65 patients underwent Fibroscan, and their results were used to evaluate the elasticity of liver tissue. Additionally, T1-mapping images were collected from 19 normal control patients. Independent sample t -tests were used to analyze the correlation between T1 mapping and Fibroscan. The diagnostic efficacy of T1 mapping in patients with different stages of liver fibrosis was evaluated using receiver operating characteristic (ROC) curves. The consistency between different observer groups was intraclass correlation coefficient (ICC) =0.802. T1 mapping demonstrated significant differences between mid-stage liver fibrosis (S = 2) and late-stage liver fibrosis (S = 3), as well as moderate inflammation (G = 2) and severe inflammation (G = 3), P  < 0.05. The Area Under Curve(AUC) values of T1 mapping for early liver fibrosis (S ≥ 1), significant liver fibrosis (S ≥ 2), advanced liver fibrosis (S ≥ 3), and end-stage liver fibrosis (S = 4) were 0.760, 0.709, 0.790, and 0.768, respectively. T1 mapping combined with Fibroscan had an AUC value of 0.860. The B1 inhomogeneity-corrected VFA T1 mapping may be useful for the staging of liver fibrosis. It has a superior diagnostic efficiency for diagnosing advanced fibrosis (≥S3), while native T1 values combined with Fibroscan have potential value for the staging of liver fibrosis.

Bibliographic Details

Zou, Jie; Jiang, Yanli; Fan, Fengxian; Yang, Pin; Gan, Tiejun; Yang, Tingli; Li, Min; Ding, Yuan; Wang, Shaoyu; Zhang, Jing

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Engineering; Medicine

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