Fabrication of bicontinuous double networks as thermal and pH stimuli responsive drug carriers for on-demand release
Materials Science and Engineering: C, ISSN: 0928-4931, Vol: 109, Page: 110495
2020
- 10Citations
- 18Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef3
- Captures18
- Readers18
- 18
Article Description
The fabrication, via a two steps approach, of a novel bicontinuous Double Network (BCDN) material is reported. We first use a bicontinuous emulsion as template to obtain a poly(butyl acrylate) (PBA) and poly(acrylic acid) (PAA) bicontinuous amphiphilic material. The material is then swollen with the precursor of a second hydrophilic polymer (PNIPAM, poly(N-isopropylacrylamide)). After polymerization of these precursors, the two responsive polymers, PNIPAM and PAA, form a double-network within a bicontinuous templated material, i.e. a bicontinuous double network (BCDN) material. The advantages of using such unique and complex double network architecture are manifold. PBA increases the mechanical properties of the hydrogel all together with the hydrophilic double network that also decouples the pH and temperature responsiveness. Among different possible applications, we tested this responsive hydrogels for its biomedical application. It can be used as pH and temperature sensitive devices for on-demand drug delivery. In addition, the release of a drug confined in the amphiphilic bicontinuous structure follows different kinetics profiles, depending on pH and temperature. This last result indicates that it is possible to control and regulate the release of an encapsulated drug according to the fluctuations of physiological conditions.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0928493119337075; http://dx.doi.org/10.1016/j.msec.2019.110495; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85076054738&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32228898; https://linkinghub.elsevier.com/retrieve/pii/S0928493119337075; https://dx.doi.org/10.1016/j.msec.2019.110495
Elsevier BV
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