Hyaluronic acid hydrogels reinforced with laser spun bioactive glass micro- and nanofibres doped with lithium
Materials Science and Engineering: C, ISSN: 0928-4931, Vol: 126, Page: 112124
2021
- 10Citations
- 38Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef8
- Captures38
- Readers38
- 38
Article Description
The repair of articular cartilage lesions in weight-bearing joints remains as a significant challenge due to the low regenerative capacity of this tissue. Hydrogels are candidates to repair lesions as they have similar properties to cartilage extracellular matrix but they are unable to meet the mechanical and biological requirements for a successful outcome. Here, we reinforce hyaluronic acid (HA) hydrogels with 13-93-lithium bioactive glass micro- and nanofibres produced by laser spinning. The glass fibres are a reinforcement filler and a platform for the delivery of therapeutic lithium-ions. The elastic modulus of the composites is more than three times higher than in HA hydrogels. Modelling of the reinforcement corroborates the experimental results. ATDC5 chondrogenic cells seeded on the composites are viable and more proliferation occurs on the hydrogels containing fibres than in HA hydrogels alone. Furthermore, the chondrogenic behavior on HA constructs with fibres containing lithium is more marked than in hydrogels with no-lithium fibres.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0928493121002630; http://dx.doi.org/10.1016/j.msec.2021.112124; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85105689924&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34082941; https://linkinghub.elsevier.com/retrieve/pii/S0928493121002630; https://dx.doi.org/10.1016/j.msec.2021.112124
Elsevier BV
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